A new hypervalent iodine(III) reagent is disclosed for 2,2-difluoroethylation of thiols, amines and alcohols via a proposed ligand coupling mechanism. A range of pharmaceutically relevant nucleophiles are difluoroethylated, including morpholine, glucose and the drugs Captopril, Normorphine and Mefloquine.

中文翻译：

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通过高价碘策略对杂原子亲核试剂进行 2,2-二氟乙基化


公开了一种新的高价碘 (III) 试剂，用于通过拟议的配体偶联机制对硫醇、胺和醇进行 2,2-二氟乙基化。一系列与药学相关的亲核试剂被二氟乙基化，包括吗啉、葡萄糖和药物卡托普利、去甲吗啡和甲氟喹。