2,2-Difluoroethylation of Heteroatom Nucleophiles via a Hypervalent Iodine Strategy,Angewandte Chemie International Edition

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2,2-Difluoroethylation of Heteroatom Nucleophiles via a Hypervalent Iodine Strategy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-06-20 , DOI: 10.1002/anie.202410954
Suman Das ₁ , Charlotte McIvor ₁ , Andrew Greener ₁ , Charlotte Suwita ₁ , Stephen P Argent ₁ , Miriam L O'Duill ₁

Affiliation

A new hypervalent iodine(III) reagent is disclosed for 2,2-difluoroethylation of thiols, amines and alcohols via a proposed ligand coupling mechanism. A range of pharmaceutically relevant nucleophiles are difluoroethylated, including morpholine, glucose and the drugs Captopril, Normorphine and Mefloquine.

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