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Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration
The Ocular Surface ( IF 5.9 ) Pub Date : 2024-06-11 , DOI: 10.1016/j.jtos.2024.06.002
Neel D Pasricha 1 , Ethan S Lindgren 2 , Rongshan Yan 2 , Yien-Ming Kuo 2 , Matilda Chan 1 , Alan S Verkman 3 , Tifany Chu 4 , Pattareeya Yottasan 4 , Livia de Souza Goncalves 4 , Onur Cil 4
Affiliation  

Ocular surface hydration is critical for eye health and its impairment can lead to dry eye disease. Extracellular calcium-sensing receptor (CaSR) is regulator of ion transport in epithelial cells expressing cystic fibrosis transmembrane conductance regulator (CFTR) Cl channel. CFTR is also a major ion channel in ocular surface epithelia, however the roles of CaSR in ocular surface are not well studied. This study aims to investigate expression and functional roles of CaSR in ocular surface.

中文翻译:


钙敏感受体 (CaSR) 调节眼表氯化物转运,其抑制作用促进眼表水合作用



眼表水合作用对眼睛健康至关重要,其损害会导致干眼症。细胞外钙敏感受体 (CaSR) 是表达囊性纤维化跨膜电导调节因子 (CFTR) Cl− 通道的上皮细胞中离子转运的调节因子。CFTR 也是眼表上皮细胞中的主要离子通道,但 CaSR 在眼表的作用尚未得到很好的研究。本研究旨在探讨 CaSR 在眼表的表达和功能作用。
更新日期:2024-06-11
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