Inflammatory bowel diseases (IBD) comprise a spectrum of chronic intestinal inflammatory diseases, mainly ulcerative colitis (UC) and Crohn’s disease (CD), with an increasing incidence worldwide.1 2 Scientific efforts and technological advances led to a profound understanding of IBD pathophysiology, helping to recognise the complex nature and heterogeneity of the IBD spectrum. In recent years, IBD has been increasingly appreciated as a systemic disease, associated with disorders affecting various organs of the body. Moreover, the complex relationship between the gut and the central nervous system (CNS) (termed ‘the gut-brain axis’) is substantially being investigated, exploring the potential causal link between many intestinal and neurological diseases.3 Several factors might explain the remarkable connection of the gut, and in particular IBD, with neurological diseases. First, chronic intestinal inflammation might damage the CNS through a systemic inflammatory response but also by dysregulating peripheral neurons in the gut.4 5 Second, disturbed interactions between luminal factors in the gut—particularly microorganisms and their metabolites—the enteric nervous system and the CNS are implicated in IBD, which impair neuron function in the CNS.6 Third, pathophysiological traits and disease mechanisms might be shared between IBD and neurologic diseases, as suggested earlier in the case of Parkinson’s disease.7 In Gut, Erkert et al …

中文翻译：

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早老素：阿尔茨海默病肠道健康的隐藏守护者


炎症性肠病 （IBD） 包括一系列慢性肠道炎症性疾病，主要是溃疡性结肠炎 （UC） 和克罗恩病 （CD），其发病率在世界范围内不断增加。2 科学努力和技术进步使人们对 IBD 病理生理学有了深刻的理解，有助于认识到 IBD 谱系的复杂性和异质性。近年来，IBD 作为一种全身性疾病越来越受到重视，与影响身体各个器官的疾病有关。此外，肠道与中枢神经系统 （CNS）（称为“肠脑轴”）之间的复杂关系正在得到大量研究，探索许多肠道和神经系统疾病之间的潜在因果关系.3 有几个因素可以解释肠道，尤其是 IBD 与神经系统疾病的显着联系。首先，慢性肠道炎症可能会通过全身炎症反应损害中枢神经系统，但也可能会使肠道中的外周神经元失调4 5 其次，肠道中管腔因子（特别是微生物及其代谢物）之间的相互作用受到干扰，肠道神经系统和中枢神经系统与炎症性肠病有关，这会损害中枢神经系统中的神经元功能6 正如前面在帕金森病的情况下所暗示的那样，IBD 和神经系统疾病之间可能具有共同的病理生理特征和疾病机制.7 在 Gut 中，Erkert 等人......