Recently, the article by Konings et al systematically articulated the association between gastrointestinal syndrome and Parkinson’s disease (PD),1 which found that appendectomy reduced the risk of PD. According to Braak’s hypothesis2 that α-synuclein aggregation may begin in the gut and be transmitted to the brain via vagus nerve, appendectomy could remove α-synuclein and vagus nerve terminals in the appendix and may further reduce α-synuclein transmission and PD risk,3 which support Konings et al ’s conclusion. However, appendectomy may also lead to the release of harmful inflammatory pathogens into the adjacent intestinal milieu and the surgical procedure itself could potentially disrupt the integrity of the intestinal environment.4 Furthermore, given the robust and diverse microbiota in human appendix, such a procedure could disrupt the gut microbiome,5 6 potentially heightening the risk of PD which is also supported by previous studies.7 8 All these factors contribute to the ongoing debate regarding the association between appendectomy and PD. Hence, we investigated the impact of appendectomy on the development of PD using the comprehensive and rich participant information collected from the UK Biobank (UKB). For this study, we analysed data involving 472 676 participants (table …

中文翻译：

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英国生物银行的阑尾切除术与帕金森病之间的关联


最近，Konings 等人的文章系统阐述了胃肠道综合征与帕金森病 (PD) 之间的关联，1 发现阑尾切除术可降低 PD 风险。根据 Braak 的假设2，α-突触核蛋白聚集可能始于肠道，并通过迷走神经传输至大脑，阑尾切除术可以去除阑尾中的 α-突触核蛋白和迷走神经末梢，并可能进一步降低 α-突触核蛋白传输和 PD 风险，3这支持了 Konings 等人的结论。然而，阑尾切除术也可能导致有害炎症病原体释放到邻近的肠道环境中，并且外科手术本身可能会破坏肠道环境的完整性。4此外，鉴于人类阑尾中强大而多样的微生物群，这样的手术可能会破坏肠道环境的完整性。破坏肠道微生物组，5 6 可能会增加 PD 风险，这也得到了先前研究的支持。7 8 所有这些因素都导致了关于阑尾切除术和 PD 之间关系的持续争论。因此，我们利用从英国生物银行 (UKB) 收集的全面而丰富的参与者信息，研究了阑尾切除术对 PD 发展的影响。在这项研究中，我们分析了涉及 472 676 名参与者的数据（表……