We developed SynTracker, a tool to track conspecific microbial strains using genome synteny. SynTracker is sensitive to genomic structural variation but not to single-nucleotide polymorphisms (SNPs). Combining SynTracker with methods for tracking strains using SNP profiles, we were able to detect species evolving by accumulating predominantly SNPs or predominantly structural variants.

中文翻译：

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追踪基因顺序为微生物群种内进化提供了新的视角


我们开发了 SynTracker，这是一种利用基因组同线性追踪同种微生物菌株的工具。 SynTracker 对基因组结构变异敏感，但对单核苷酸多态性 (SNP) 不敏感。将 SynTracker 与使用 SNP 图谱追踪菌株的方法相结合，我们能够通过主要积累 SNP 或主要结构变异来检测物种的进化。