Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with innate immunity having a secondary role. The finding that recipient natural killer cells are activated by the inability of graft endothelial cells to provide HLA-I-mediated inhibitory signals challenges this dogma and introduces the concept of innate rejection.

中文翻译：

---

自然杀伤细胞介导的先天性微血管排斥反应


移植排斥传统上归因于识别供体特异性同种抗原的适应性免疫细胞，先天免疫发挥次要作用。移植物内皮细胞无法提供 HLA-I 介导的抑制信号，从而激活受体自然杀伤细胞，这一发现挑战了这一教条，并引入了先天排斥的概念。