Natural killer cell-mediated innate microvascular rejection,Nature Reviews Nephrology

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Natural killer cell-mediated innate microvascular rejection
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2024-06-19 , DOI: 10.1038/s41581-024-00862-w
Olivier Thaunat _{1,

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Affiliation

Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with innate immunity having a secondary role. The finding that recipient natural killer cells are activated by the inability of graft endothelial cells to provide HLA-I-mediated inhibitory signals challenges this dogma and introduces the concept of innate rejection.

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