In this article, a novel and practical approach was presented for the synthesis of deoxycholic acid (1) from cholic acid (2). The synthesis pathway involved the obtention of acid (20) from compound 2 via selective oxidation, followed by the condensation of 20 with p-toluenesulfonylhydrazine (23) to form hydrazones (21). Subsequently, product 1 was generated through a three-step reaction process involving reduction by NaBH₄. The overall yield achieved 62.9%, with an HPLC purity of 100.00%. Structural confirmation of all compounds was performed using ¹H NMR and ¹³C NMR spectroscopy as well as HRMS.

中文翻译：

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胆酸新颖便捷合成脱氧胆酸


在本文中，提出了一种从胆酸 (2) 合成脱氧胆酸 (1) 的新颖且实用的方法。合成途径包括通过选择性氧化从化合物2中得到酸(20)，然后20与对甲苯磺酰肼(23)缩合形成腙(21)。随后，通过NaBH ₄ 还原的三步反应过程生成产物1。总收率达到62.9%，HPLC纯度为100.00%。所有化合物的结构确认均使用 ¹ H NMR 和 ¹³ C NMR 光谱以及HRMS 进行。