Carbazole derivatives are vital in medicinal and materials chemistry, yet accessing diverse substitutions remains challenging. Here, we introduce a regioselective approach for C1 and C8 alkynylation of carbazoles via palladium-catalyzed C‒H activation. This method provides a direct route to mono- and di-alkynylated derivatives, addressing the scarcity of alkynylated carbazole-based materials. Our study broadens the synthetic toolbox for carbazole functionalization, offering potential applications in optoelectronics, bio-imaging, and beyond, while contributing to developing sustainable C‒H activation methodologies.

中文翻译：

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钯催化咔唑与炔基溴的直接炔基化反应


咔唑衍生物在医药和材料化学中至关重要，但获得多种替代品仍然具有挑战性。在这里，我们介绍了一种通过钯催化的 C-H 活化对咔唑进行 C1 和 C8 炔基化的区域选择性方法。该方法提供了制备单炔基化衍生物和二炔基化衍生物的直接途径，解决了炔基化咔唑基材料的稀缺问题。我们的研究拓宽了咔唑功能化的合成工具箱，提供了在光电子学、生物成像等领域的潜在应用，同时有助于开发可持续的 C-H 活化方法。