The total syntheses of gochnatiolide D and ainsliadimer A were achieved through a streamlined one-pot sequence starting from their biogenetic precursor dehydrozaluzanin C. These biomimetic, protecting group-free syntheses involve the elegant orchestration of the highly diastereoselective hetero-Diels-Alder reaction of dehydrozaluzanin C, its subsequent hydrolysis to gochnatiolide D and finally an aldol reaction to ainsliadimer A, all harnessed by the hydrogen bond propensity and acidity of hexafluoroisopropanol (HFIP), which was utilized as the reaction solvent.

中文翻译：

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HFIP 促进从脱氢扎鲁扎宁 C 短时间全合成 Gochnatiolide D 和 Ainsliadimer A


gochnatiolide D 和 ainsliadimer A 的全合成是通过从它们的生物前体 dehydrozaluzanin C 开始的简化的一锅法序列实现的。这些仿生、无保护基团的合成涉及脱氢zaluzanin 的高度非对映选择性杂 Diels-Alder 反应的优雅编排C，随后水解为 gochnatiolide D，最后通过羟醛反应生成 ainsliadimer A，所有这些都是通过六氟异丙醇 (HFIP) 的氢键倾向和酸性来利用的，六氟异丙醇 (HFIP) 用作反应溶剂。