Sodium glucose cotransporters (SGLTs) transport glucose against its concentration gradient by harnessing the electrochemical potential gradient of sodium ions. SGLT inhibitors are widely prescribed to treat diabetes and other conditions. Recent structural studies have uncovered how chemically diverse SGLT inhibitors bind and inhibit the transporter at the atomic level.

中文翻译：

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结构揭示了 SGLT 抑制剂的工作原理

钠葡萄糖协同转运蛋白 (SGLT) 通过利用钠离子的电化学势梯度逆其浓度梯度转运葡萄糖。 SGLT 抑制剂广泛用于治疗糖尿病和其他疾病。最近的结构研究揭示了化学多样性的 SGLT 抑制剂如何在原子水平上结合和抑制转运蛋白。