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4-tert-Butylphenol impairs the liver by inducing excess liver lipid accumulation via disrupting the lipid metabolism pathway in zebrafish
Environmental Pollution ( IF 7.6 ) Pub Date : 2024-06-17 , DOI: 10.1016/j.envpol.2024.124385 Huiyun Wang 1 , Juan Liu 1 , Shuting Qiang 1 , Yufeng Che 1 , Tingzhang Hu 1
Environmental Pollution ( IF 7.6 ) Pub Date : 2024-06-17 , DOI: 10.1016/j.envpol.2024.124385 Huiyun Wang 1 , Juan Liu 1 , Shuting Qiang 1 , Yufeng Che 1 , Tingzhang Hu 1
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Endocrine disrupting chemicals (EDCs) can disrupt normal endocrine function by interfering with the synthesis and release of hormones, causing adverse reactions to development, immunity, nerves, and reproduction. 4--Butylphenol (4--BP) is disruptive to early zebrafish development, but its effects on zebrafish liver are unknown. In this study, the adverse effects of 4--BP on the liver were investigated using zebrafish as a model organism. 4--BP inhibited liver development in zebrafish embryos and induced liver damage in adult zebrafish. Even if F1 was not directly exposed to 4--BP, its growth and development were inhibited. 4--BP can lead to an increase in lipid accumulation, total cholesterol and triglycerides contents, and the activities of alanine transaminase and aspartate aminotransferase in zebrafish embryos and adult zebrafish livers, and also cause an acceleration of glucose metabolism in zebrafish embryos. In addition, qRT-PCR showed that 4--BP induced the changes in the expressions of liver development-, steroid and unsaturated fatty acid biosynthesis-, and glycerolipid and arachidonic acid metabolism-related genes in zebrafish embryos and inflammatory factors-, antioxidant enzymes- and lipid metabolism-related genes in adult zebrafish livers. Transcriptome sequencing of embryos showed that 4--BP altered the expressions of lipid metabolism pathways such as steroid and unsaturated fatty acid biosynthesis, glycerolipid, and arachidonic acid metabolism pathways. Therefore, 4--BP may be external stimuli that cause oxidative stress, inflammation, and lipid accumulation in zebrafish liver, resulting in tissue damage and dysfunction in zebrafish liver.
中文翻译：
4-叔丁基苯酚通过破坏斑马鱼的脂质代谢途径，诱导过量的肝脏脂质积累，从而损害肝脏
内分泌干扰物（EDC）可通过干扰激素的合成和释放来破坏正常的内分泌功能，对发育、免疫、神经和生殖造成不良反应。 4-丁基苯酚 (4--BP) 会破坏斑马鱼的早期发育，但其对斑马鱼肝脏的影响尚不清楚。本研究以斑马鱼为模型生物，研究了 4--BP 对肝脏的不良影响。 4--BP抑制斑马鱼胚胎的肝脏发育并诱导成年斑马鱼的肝脏损伤。即使F1不直接接触4--BP，其生长发育也会受到抑制。 4--BP可导致斑马鱼胚胎和成年斑马鱼肝脏中脂质积累、总胆固醇和甘油三酯含量以及丙氨酸转氨酶和天冬氨酸转氨酶活性增加，并导致斑马鱼胚胎中葡萄糖代谢加速。此外，qRT-PCR显示4--BP诱导斑马鱼胚胎中肝脏发育、类固醇和不饱和脂肪酸生物合成、甘油脂和花生四烯酸代谢相关基因以及炎症因子、抗氧化酶表达的变化。 - 成年斑马鱼肝脏中与脂质代谢相关的基因。胚胎转录组测序表明，4--BP改变了类固醇和不饱和脂肪酸生物合成、甘油脂和花生四烯酸代谢途径等脂质代谢途径的表达。因此，4--BP可能是外界刺激引起斑马鱼肝脏氧化应激、炎症和脂质堆积，导致斑马鱼肝脏组织损伤和功能障碍。
更新日期：2024-06-17
中文翻译：
4-叔丁基苯酚通过破坏斑马鱼的脂质代谢途径，诱导过量的肝脏脂质积累，从而损害肝脏
内分泌干扰物（EDC）可通过干扰激素的合成和释放来破坏正常的内分泌功能，对发育、免疫、神经和生殖造成不良反应。 4-丁基苯酚 (4--BP) 会破坏斑马鱼的早期发育，但其对斑马鱼肝脏的影响尚不清楚。本研究以斑马鱼为模型生物，研究了 4--BP 对肝脏的不良影响。 4--BP抑制斑马鱼胚胎的肝脏发育并诱导成年斑马鱼的肝脏损伤。即使F1不直接接触4--BP，其生长发育也会受到抑制。 4--BP可导致斑马鱼胚胎和成年斑马鱼肝脏中脂质积累、总胆固醇和甘油三酯含量以及丙氨酸转氨酶和天冬氨酸转氨酶活性增加，并导致斑马鱼胚胎中葡萄糖代谢加速。此外，qRT-PCR显示4--BP诱导斑马鱼胚胎中肝脏发育、类固醇和不饱和脂肪酸生物合成、甘油脂和花生四烯酸代谢相关基因以及炎症因子、抗氧化酶表达的变化。 - 成年斑马鱼肝脏中与脂质代谢相关的基因。胚胎转录组测序表明，4--BP改变了类固醇和不饱和脂肪酸生物合成、甘油脂和花生四烯酸代谢途径等脂质代谢途径的表达。因此，4--BP可能是外界刺激引起斑马鱼肝脏氧化应激、炎症和脂质堆积，导致斑马鱼肝脏组织损伤和功能障碍。
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