Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras,Lab Animal

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Crossing species boundaries in regenerative neuroscience with rat–mouse brain chimeras
Lab Animal ( IF 5.9 ) Pub Date : 2024-06-17 , DOI: 10.1038/s41684-024-01394-3
Stefano Pluchino ₁ , Ivan Lombardi _{1,

2}

Affiliation

Understanding the inherent complexity of organogenesis and addressing the persistent shortage of organ donors remain paramount scientific challenges. Recent advances in chimeric blastocyst technology offer promising solutions. Two new pioneering studies have successfully generated functional rat–mouse brain chimeras, providing novel insights into brain development and potential regenerative therapies. However, several technical and ethical hurdles persist.

中文翻译：

利用大鼠-小鼠大脑嵌合体跨越再生神经科学的物种界限

了解器官发生的内在复杂性并解决器官捐献者持续短缺的问题仍然是最重要的科学挑战。嵌合囊胚技术的最新进展提供了有希望的解决方案。两项新的开创性研究成功地产生了功能性大鼠-小鼠大脑嵌合体，为大脑发育和潜在的再生疗法提供了新的见解。然而，一些技术和道德障碍仍然存在。

更新日期：2024-06-18

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