Herein, we report a practical synthetic method for the efficient preparation of fluoroalkylated quinoline-2,4-diones using N-(2-cyanophenyl)-N-methylacrylamides as substrates, fluoroalkyl carboxylic acids as reactants, and Fe(OH)(OAc)₂ as a catalyst. This reaction started with a photo-driven ligand-to-metal charge transfer (LMCT) process to decarboxylate the reactant and produce fluoroalkyl radicals, which then underwent radical cascade cyclization with the substrate. The target products were obtained in 55–91% yields. A gram scale experiment was also completed using a continuous-flow photocatalytic device.

中文翻译：

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通过铁催化 LMCT 脱羧过程光诱导合成氟烷基喹啉酮


在此，我们报道了一种以 N-(2-氰基苯基)-N-甲基丙烯酰胺为底物、氟烷基羧酸为反应物和 Fe(OH)(OAc) 有效制备氟烷基化喹啉-2,4-二酮的实用合成方法 ₂ 作为催化剂。该反应始于光驱动的配体到金属电荷转移（LMCT）过程，使反应物脱羧并产生氟烷基自由基，然后与底物进行自由基级联环化。目标产物的收率达到 55-91%。还使用连续流光催化装置完成了克级实验。