A Lewis acid-catalyzed phosphinoylation and halogenation of α,β-unsaturated ketones to synthesize γ-halo allylic phosphonates is described. This transformation consists of a phospha-Michael addition, unimolecular elimination dehydration cascade reaction for the introduction of versatile groups (–P(O)R₃R₄ and –X) in the resulting γ-substituted allylic phosphonates with high regio- and stereoselectivity.

中文翻译：

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路易斯酸催化α,β-不饱和酮的膦酰化和卤化：获得γ-卤代烯丙膦酸酯


描述了路易斯酸催化 α,β-不饱和酮的膦酰化和卤化来合成 γ-卤代烯丙膦酸酯。该转化包括磷酸-迈克尔加成、单分子消除脱水级联反应，以在所得产物中引入多功能基团（-P(O)R ₃ R ₄ 和 -X）具有高区域选择性和立体选择性的γ-取代烯丙基膦酸酯。