Single-atom editing, which involves precise modifications to a ring system through the selective insertion, deletion or substitution of atoms, represents a crucial advancement in the manipulation of chemically active molecules. This review focuses primarily on the editing of nitrogen atoms, including the insertion of N, the substitution of C with N and ¹⁴N with ¹⁵N for the construction of N-heterocycles. The emphasis on the nitrogen source facilitates a deeper understanding of the reactions involved. We anticipate that this review will not only underscore the innovative and enabling capabilities of current nitrogen single-atom editing techniques but also highlight the significant opportunities and untapped possibilities within this emerging and valuable field.

中文翻译：

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精确单原子编辑：氮插入和取代生成氮杂环的新领域


单原子编辑涉及通过选择性插入、删除或替换原子对环系统进行精确修改，代表了化学活性分子操纵方面的重大进步。本综述主要关注氮原子的编辑，包括N的插入、C与N的取代以及 ¹⁴ N与 ¹⁵ N的取代以构建N-杂环。对氮源的强调有助于更深入地了解所涉及的反应。我们预计这次审查不仅将强调当前氮单原子编辑技术的创新和实现能力，还将强调这一新兴且有价值的领域中的重大机遇和未开发的可能性。