Herein, a concise protocol for the construction of axially chiral biaryls via Pd-catalysed direct C–H arylation of 1-arylisoquinoline N-oxides through kinetic resolution using a commercially available, cost-effective, and bench-stable chiral mono-protected amino acid has been uncovered. The high conformational stability of the axially chiral products in different solvents and at high temperatures, as observed from the experimental studies and DFT calculations, shows their excellent stability.

中文翻译：

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通过 Pd(II) 催化直接 C(sp2)–H 芳基化合成轴向手性联芳基化合物


在此，通过使用市售的、经济高效且实验室稳定的手性单保护氨基酸通过动力学拆分，通过 Pd 催化的 1-芳基异喹啉 N-氧化物的直接 C-H 芳基化来构建轴向手性联芳基的简明协议已经被发现。从实验研究和DFT计算观察到，轴向手性产物在不同溶剂和高温下具有高构象稳定性，显示出其优异的稳定性。