Chronic wounds represent a major global health problem, causing staggering economic and social burdens. The pursuit of effective wound healing strategies demands a multidisciplinary approach, and advances in material sciences and bioengineering have paved the way for the development of novel wound healing biomaterials and technologies. In this Review, we provide an overview of the history and challenges of wound management and highlight the current state of the art in wound healing biomaterials alongside the emerging technologies poised to transform the landscape of chronic wound treatment and monitoring. Moreover, we discuss the clinical and commercial considerations associated with wound healing strategies, including the regulatory pathways and key steps in the translational process. Furthermore, we highlight existing translational gaps and offer a nuanced understanding of the challenges that persist in translating innovative concepts into mainstream clinical practices. Continued innovations and interdisciplinary collaboration will pave the way for better wound care outcomes and potentially markedly improved quality of life for a steadily increasing and ageing population.

慢性伤口是一个重大的全球健康问题，造成了惊人的经济和社会负担。追求有效的伤口愈合策略需要采用多学科方法，材料科学和生物工程的进步为新型伤口愈合生物材料和技术的开发铺平了道路。在这篇综述中，我们概述了伤口管理的历史和挑战，并重点介绍了伤口愈合生物材料的最新技术以及有望改变慢性伤口治疗和监测格局的新兴技术。此外，我们讨论了与伤口愈合策略相关的临床和商业考虑因素，包括转化过程中的监管途径和关键步骤。此外，我们强调现有的转化差距，并对将创新概念转化为主流临床实践中持续存在的挑战提供细致入微的理解。持续的创新和跨学科合作将为更好的伤口护理结果铺平道路，并可能显着改善人口稳步增长和老龄化的生活质量。