The recent Consensus Statement on the diagnosis and management of prolactin-secreting pituitary adenomas (prolactinomas) drew attention to molecular pathogenetic mechanisms. We comment that somatic screening for SF3B1 hotspot variants in select cases might alert to aggressive tumour behaviour and prompt the timely management and intense follow up of these challenging tumours.

中文翻译：

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侵袭性催乳素瘤体细胞突变筛查的证据


最近关于分泌催乳素的垂体腺瘤（催乳素瘤）的诊断和治疗的共识声明引起了人们对分子发病机制的关注。我们评论说，在某些病例中对 SF3B1 热点变异进行体细胞筛查可能会警惕侵袭性肿瘤行为，并促进对这些具有挑战性的肿瘤的及时管理和密切随访。