The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation. Under normal physiological conditions, the Wnt/β-catenin signaling pathway is meticulously regulated. However, aberrant activation of this pathway and downstream target genes can occur due to mutations in key components of the Wnt/β-catenin pathway, epigenetic modifications, and crosstalk with other signaling pathways. Consequently, these dysregulations contribute significantly to tumor initiation and progression. Therapies targeting the Wnt/β-catenin signaling transduction have exhibited promising prospects and potential for tumor treatment. An increasing number of medications targeting this pathway are continuously being developed and validated. This comprehensive review aims to summarize the latest advances in our understanding of the role played by the Wnt/β-catenin signaling pathway in carcinogenesis and targeted therapy, providing valuable insights into acknowledging current opportunities and challenges associated with targeting this signaling pathway in cancer research and treatment.

中文翻译：

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Wnt/β-catenin 信号通路在癌变和癌症治疗中的应用


Wnt/β-catenin 信号通路在各种生理过程中起着至关重要的作用，包括发育、组织稳态和细胞增殖。在正常生理条件下，Wnt/β-catenin 信号通路受到精心调控。然而，由于 Wnt/β-catenin 通路关键组分的突变、表观遗传修饰以及与其他信号通路的串扰，可能会发生该通路和下游靶基因的异常激活。因此，这些失调对肿瘤的发生和进展有重大影响。靶向 Wnt/β-catenin 信号转导的疗法在肿瘤治疗方面显示出良好的前景和潜力。越来越多的靶向该通路的药物正在不断开发和验证。本综述旨在总结我们对 Wnt/β-catenin 信号通路在致癌作用和靶向治疗中的作用的理解的最新进展，为认识癌症研究和治疗中与靶向该信号通路相关的当前机遇和挑战提供有价值的见解。