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A Direct Approach to a 6-Hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine Library
Organic Letters ( IF 4.9 ) Pub Date : 2013-12-30 00:00:00 , DOI: 10.1021/ol403308h Nadezhda V. Palysaeva 1 , Katerina P. Kumpan 1 , Marina I. Struchkova 1 , Igor L. Dalinger 1 , Aleksandr V. Kormanov 1 , Nataly S. Aleksandrova 1 , Victor M. Chernyshev 2 , Dmitrii F. Pyreu 3 , Kyrill Yu. Suponitsky 4 , Aleksei B. Sheremetev 1
Organic Letters ( IF 4.9 ) Pub Date : 2013-12-30 00:00:00 , DOI: 10.1021/ol403308h Nadezhda V. Palysaeva 1 , Katerina P. Kumpan 1 , Marina I. Struchkova 1 , Igor L. Dalinger 1 , Aleksandr V. Kormanov 1 , Nataly S. Aleksandrova 1 , Victor M. Chernyshev 2 , Dmitrii F. Pyreu 3 , Kyrill Yu. Suponitsky 4 , Aleksei B. Sheremetev 1
Affiliation
The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.
中文翻译：
6-Hetarylamino [1,2,4] triazolo [4,3- b ] [1,2,4,5]四嗪文库的直接方法
报道了6-杂芳基氨基[1,2,4]三唑并[4,3- b ] [1,2,4,5]四嗪的合成。通过K 2 CO 3介导的弱碱性杂芳基胺与3-（3,5-二甲基吡唑-1-基）[1,2,4]三唑[4,3- b ]的S N Ar反应构建官能化的仲胺。] [1,2,4,5]四嗪，可取代3,5-二甲基吡唑基离去基团。显着地，该反应展现出宽的底物范围并且以良好的产率进行。
更新日期：2013-12-30
中文翻译：
6-Hetarylamino [1,2,4] triazolo [4,3- b ] [1,2,4,5]四嗪文库的直接方法
报道了6-杂芳基氨基[1,2,4]三唑并[4,3- b ] [1,2,4,5]四嗪的合成。通过K 2 CO 3介导的弱碱性杂芳基胺与3-（3,5-二甲基吡唑-1-基）[1,2,4]三唑[4,3- b ]的S N Ar反应构建官能化的仲胺。] [1,2,4,5]四嗪，可取代3,5-二甲基吡唑基离去基团。显着地，该反应展现出宽的底物范围并且以良好的产率进行。
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