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Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
Cell Research ( IF 28.1 ) Pub Date : 2024-06-18 , DOI: 10.1038/s41422-024-00988-3 Ella Hartenian 1 , Petr Broz 1
中文翻译:
焦亡:棕榈酰化调节 GSDMD 活化和孔形成
更新日期:2024-06-18
Cell Research ( IF 28.1 ) Pub Date : 2024-06-18 , DOI: 10.1038/s41422-024-00988-3 Ella Hartenian 1 , Petr Broz 1
Affiliation
Gasdermin D (GSDMD) is the pore-forming executor of pyroptosis and cytokine secretion during inflammasome activation. In a recent study in Nature, Du et al. report that S-palmitoylation of human GSDMD at Cys191 (mouse Cys192) is a key regulatory step that controls both its activation and interaction with membranes.
中文翻译:
焦亡:棕榈酰化调节 GSDMD 活化和孔形成
Gasdermin D (GSDMD) 是炎性小体激活过程中细胞焦亡和细胞因子分泌的成孔执行剂。在最近发表在《自然》杂志上的一项研究中,Du 等人报告了人 GSDMD 在 Cys191(小鼠 Cys192)位点的 S-棕榈酰化是控制其激活和与膜相互作用的关键调节步骤。