The catalytic asymmetric synthesis of voriconazole, a synthetically challenging antifungal agent was achieved in nine steps with a 8 % overall yield. This novel strategy relied on the precise synthesis of tetrasubstituted (Z)-allylic alcohol and the subsequent highly efficient epoxidation to establish the critical contiguous carbon stereocenters in a single step.

中文翻译：

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四取代(Z)-烯烃不对称环氧化对映选择性合成抗真菌药伏立康唑


伏立康唑（一种合成上具有挑战性的抗真菌剂）的催化不对称合成通过九个步骤实现，总产率为 8%。这种新颖的策略依赖于四取代（Z）-烯丙醇的精确合成以及随后的高效环氧化，以一步建立关键的连续碳立构中心。