Omics is a discipline that identifies and quantifies molecular processes that contribute to the form and function of living systems. Here, we translate omics to study battery systems. By employing precision analytical capabilities across chemical space, we delineate the structure, function, and evolution of interphases when cycling Li-nickel manganese oxide (NMC)811 cells at high power and high voltage with mixed-salt locally superconcentrated electrolytes. Despite differences in their make-up, top-performing electrolytes converged in their cathode–electrolyte interphase (CEI) chemistries, which were unexpectedly enriched with fluoroethers (upregulation) and depleted with LiF (downregulation). Moreover, these atypical CEIs more effectively suppressed leakage current, cathode corrosion, and cathode fracturing, extending battery life. Pouch cells (130 mAh) assembled with 50-μm-thick Li foil, semi-solid NMC811 electrodes (9 mAh cm⁻²), and lean electrolyte (2.2 Ah g⁻¹) showed excellent power retention over more than 100 cycles using a realistic mission for electric vertical take-off and landing.

组学是一门识别和量化有助于生命系统的形式和功能的分子过程的学科。在这里，我们将组学转化为研究电池系统。通过利用跨化学空间的精确分析能力，我们描述了使用混合盐局部超浓缩电解质在高功率和高电压下循环锂镍锰氧化物 (NMC)811 电池时界面的结构、功能和演化。尽管其组成存在差异，但性能最佳的电解质集中在其阴极电解质界面（CEI）化学成分中，其中出人意料地富含氟醚（上调）和缺乏LiF（下调）。此外，这些非典型CEIs更有效地抑制了漏电流、阴极腐蚀和阴极破裂，延长了电池寿命。使用 50 μm 厚的锂箔、半固态 NMC811 电极 (9 mAh cm ^-2 ) 和贫电解液 (2.2 Ah g ^-1 ) 组装的软包电池 (130 mAh) 在超过 100 次循环后表现出优异的功率保持能力电动垂直起降的现实任务。