Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: Data from STRONG-HF,European Journal of Heart Failure

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Biologically active adrenomedullin as a marker for residual congestion and early rehospitalization in patients hospitalized for acute heart failure: Data from STRONG-HF
European Journal of Heart Failure ( IF 16.9 ) Pub Date : 2024-06-14 , DOI: 10.1002/ejhf.3336
Geert Voordes ₁ , Beth Davison _{2,

3,

4,

5} , Jan Biegus ₆ , Christopher Edwards ₄ , Kevin Damman ₁ , Jozine Ter Maaten ₁ , Alexandre Mebazaa _{2,

3} , Koji Takagi ₄ , Marianna Adamo ₇ , Andrew P Ambrosy _{8,

9} , Mattia Arrigo ₁₀ , Marianela Barros ₄ , Jelena Celutkiene ₁₁ , Kamilė Čerlinskaitė-Bajorė ₁₁ , Ovidiu Chioncel ₁₂ , Alain Cohen-Solal ₁₃ , Albertino Damasceno ₁₄ , Benjamin Deniau _{2,

3} , Rafael Diaz ₁₅ , Gerasimos Filippatos ₁₆ , Etienne Gayat _{2,

3} , Antoine Kimmoun ₁₇ , Carolyn S P Lam _{18,

19,

20} , Marco Metra ₇ , Maria Novosadova ₄ , Matteo Pagnesi ₇ , Peter Pang ₂₁ , Piotr Ponikowski ₆ , Hadiza Saidu ₂₂ , Karen Sliwa ₂₃ , Daniela Tomasoni ₇ , Gad Cotter _{2,

3,

4,

5} , Adriaan A Voors ₁

Affiliation

Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Université Paris Cité, INSERM UMR-S 942 (MASCOT), Paris, France.
Department of Anesthesiology and Critical Care and Burn Unit, Saint-Louis and Lariboisière Hospitals, FHU PROMICE, DMU Parabol, APHP Nord, Paris, France.
Momentum Research, Durham, NC, USA.
Heart initiative, Durham, NC, USA.
Institute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Cardiology, Cardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Department of Cardiology, Kaiser Permanente San Francisco Medical Center, San Francisco, CA, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Department of Internal Medicine, Stadtspital Zurich, Zurich, Switzerland.
Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Emergency Institute for Cardiovascular Diseases 'Prof. C.C. Iliescu', University of Medicine 'Carol Davila', Bucharest, Romania.
APHP Nord, Department of Cardiology, Lariboisière University Hospital, Paris, France.
Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Estudios Clínicos Latinoamérica, Instituto Cardiovascular de Rosario, Rosario, Argentina.
National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
Université de Lorraine, Nancy; INSERM, Défaillance Circulatoire Aigue et Chronique; Service de Médecine Intensive et Réanimation Brabois, CHRU de Nancy, Vandœuvre-lès-Nancy, France.
National Heart Centre Singapore and Duke-National University of Singapore, Singapore, Singapore.
Baim Institute for Clinical Research, Boston, MA, USA.
University Medical Centre Groningen, Groningen, The Netherlands.
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Murtala Muhammed Specialist Hospital, Bayero University Kano, Kano, Nigeria.
Division of Cardiology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Biologically active adrenomedullin (bio-ADM) is a promising marker of residual congestion. The STRONG-HF trial showed that high-intensity care (HIC) of guideline-directed medical therapy (GDMT) improved congestion and clinical outcomes in heart failure (HF) patients. The association between bio-ADM, decongestion, outcomes and the effect size of HIC of GDMT remains to be elucidated.

中文翻译：

生物活性肾上腺髓质素作为急性心力衰竭住院患者残余充血和早期再住院的标志物：来自 STRONG-HF 的数据

生物活性肾上腺髓质素（bio-ADM）是一种很有前景的残留充血标志物。 STRONG-HF 试验表明，指南指导的药物治疗 (GDMT) 的高强度护理 (HIC) 可改善心力衰竭 (HF) 患者的充血和临床结果。生物 ADM、减充血、结果和 GDMT 的 HIC 效应大小之间的关联仍有待阐明。

更新日期：2024-06-14

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