Social memory, the ability to recognize and remember individuals within a social group, is crucial for social interactions and relationships. Deficits in social memory have been linked to several neuropsychiatric and neurodegenerative disorders. The hippocampus, especially the circuit that links dorsal CA2 and ventral CA1 neurons, is considered a neural substrate for social memory formation. Recent studies have provided compelling evidence of extrahippocampal contributions to social memory. The septal nuclei, including the medial and lateral septum, make up a basal forebrain region that shares bidirectional neuronal connections with the hippocampus and has recently been identified as critical for social memory. The focus of our review is the neural circuit mechanisms that underlie social memory, with a special emphasis on the septum. We also discuss the social memory dysfunction associated with neuropsychiatric and neurodegenerative disorders.

中文翻译：

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海马外对社会记忆的贡献：间隔核的作用


社交记忆，即识别和记住社会群体中个人的能力，对于社交互动和人际关系至关重要。社交记忆缺陷与多种神经精神和神经退行性疾病有关。海马体，尤其是连接背侧 CA2 和腹侧 CA1 神经元的回路，被认为是社会记忆形成的神经基质。最近的研究提供了令人信服的证据，证明海马外对社会记忆有贡献。隔膜核，包括内侧和外侧隔膜，构成一个与海马体共享双向神经元连接的基底前脑区域，最近已被确定为对社交记忆至关重要。我们综述的重点是构成社会记忆基础的神经回路机制，特别强调隔膜。我们还讨论了与神经精神和神经退行性疾病相关的社会记忆功能障碍。