Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study,Biological Psychiatry

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Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study
Biological Psychiatry ( IF 9.6 ) Pub Date : 2024-05-03 , DOI: 10.1016/j.biopsych.2024.04.016
Tianyuan Lu ₁ , Yiheng Chen ₂ , Satoshi Yoshiji ₃ , Yann Ilboudo ₄ , Vincenzo Forgetta ₅ , Sirui Zhou ₆ , Celia Mt Greenwood ₇

Affiliation

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; 5 Prime Sciences, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada; Kyoto-McGill International Collaborative Program in Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Japan Society for the Promotion of Science, Japan.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada.
5 Prime Sciences, Montréal, Québec, Canada.
Department of Human Genetics, McGill University, Montréal, Québec, Canada; McGill Genome Centre, McGill University, Montréal, Québec, Canada.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Department of Human Genetics, McGill University, Montréal, Québec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada; Gerald Bronfman Department of Oncology, McGill University, Montréal, Québec, Canada.

Preventive measures and treatments for psychiatric disorders are limited. Circulating metabolites are potential candidates for biomarker and therapeutic target identification, given their measurability and essential roles in biological processes.

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