Wound management remains a great challenge for clinicians due to the complex physiological process of wound healing. Porous silicon (PSi) with controlled pore morphology, abundant surface chemistry, unique photonic properties, good biocompatibility, easy biodegradation and potential bioactivity represent an exciting class of materials for various biomedical applications. In this review, we focus on the recent progress of PSi in the design of advanced sensing and delivery systems for wound management applications. Firstly, we comprehensively introduce the common type, normal healing process, delaying factors and therapeutic drugs of wound healing. Subsequently, the typical fabrication, functionalization and key characteristics of PSi have been summarized because they provide the basis for further use as biosensing and delivery materials in wound management. Depending on these properties, the rise of PSi materials is evidenced by the examples in literature in recent years, which has emphasized the robust potential of PSi for wound monitoring, treatment and theranostics. Finally, challenges and opportunities for the future development of PSi-based sensors and delivery systems for wound management applications are proposed and summarized. We hope that this review will help readers to better understand current achievements and future prospects on PSi-based sensing and delivery systems for advanced wound management.

中文翻译：

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用于伤口管理应用的多孔硅传感和输送平台


由于伤口愈合的复杂生理过程，伤口管理对临床医生来说仍然是一个巨大的挑战。多孔硅（PSi）具有受控的孔隙形态、丰富的表面化学性质、独特的光子特性、良好的生物相容性、易于生物降解和潜在的生物活性，代表了一类令人兴奋的用于各种生物医学应用的材料。在这篇综述中，我们重点关注 PSi 在伤口管理应用的先进传感和输送系统设计方面的最新进展。首先全面介绍伤口愈合的常见类型、正常愈合过程、延迟因素及治疗药物。随后，总结了 PSi 的典型制造、功能化和关键特性，因为它们为进一步用作伤口处理中的生物传感和递送材料提供了基础。根据这些特性，近年来文献中的例子证明了 PSi 材料的兴起，这些例子强调了 PSi 在伤口监测、治疗和治疗诊断方面的强大潜力。最后，提出并总结了用于伤口管理应用的基于 PSi 的传感器和输送系统未来发展的挑战和机遇。我们希望这篇综述能够帮助读者更好地了解基于 PSi 的先进伤口管理传感和输送系统的当前成就和未来前景。