Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic outcomes. Transdermal drug delivery based on various delivery strategies can offer improved therapeutic potential and superior patient experiences. Recently, there has been increased foundational and clinical research focusing on the role of the transdermal route in gene delivery and exploring its impact on the efficiency of gene delivery. This review introduces the recent advances in transdermal gene delivery approaches facilitated by drug formulations and medical devices, as well as discusses their prospects.

中文翻译：

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透皮基因递送


基因传递彻底改变了疫苗接种、癌症和自身免疫性疾病的传统医学方法。然而，目前的基因递送方法仅限于静脉注射或直接局部注射，未能实现良好的生物安全性、组织靶向性、药物保留和转染效率以达到预期的治疗效果。基于各种递送策略的透皮药物递送可以提供改进的治疗潜力和卓越的患者体验。最近，越来越多的基础和临床研究集中在透皮途径在基因递送中的作用并探索其对基因递送效率的影响。本综述介绍了药物制剂和医疗设备促进的透皮基因递送方法的最新进展，并讨论了它们的前景。