To characterize structural differences and assess the diagnostic accuracy of optic nerve head (ONH) and macula optical coherence tomography (OCT) parameters to detect glaucoma in eyes with and without high axial myopia. Cross-sectional study. Three hundred sixty-eight glaucoma and 411 healthy eyes with no axial myopia, 393 glaucoma and 271 healthy eyes with mild axial myopia and 124 glaucoma and 85 healthy eyes with high axial myopia were included. Global and sectoral peripapillary retinal nerve fiber layer thickness (pRNFLT), Bruch's membrane opening minimum rim width (BMO-MRW), ganglion cell inner plexiform layer thickness (GCIPLT), and macula RNFLT (mRNFLT) were compared and the diagnostic accuracy for glaucoma detection was evaluated using the adjusted area under the receiver operating characteristic curve (AUC). Diagnostic accuracy for ONH and macula parameters to detect glaucoma was generally high and differed by myopia group. For ONH parameters the diagnostic accuracy was highest for global (AUC = 0.95) and inferotemporal (AUC = 0.91) pRNFLT for high myopes and global BMO-MRW for nonmyopes (AUC = 1.0) and mild myopes (AUC = 0.97). For macula parameters, the diagnostic accuracy was higher in high myopes with 6 of the 11 GCIPLT global/sectors having adjusted AUCs > 0.90 compared to nonhigh myopes with no AUCs > 0.90. In all myopia groups, mRNFLT had lower AUCs than GCIPLT. The diagnostic accuracy for pRNFL and GCIPL was high for high axial myopic eyes and shows promise for glaucoma detection in high myopes. Further analysis is needed to determine whether the high diagnostic accuracy can be confirmed in other populations.

中文翻译：

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视神经乳头和黄斑 OCT 参数对患有和不患有高度轴性近视眼青光眼的诊断准确性


表征结构差异并评估视神经乳头 (ONH) 和黄斑光学相干断层扫描 (OCT) 参数的诊断准确性，以检测患有和不患有高度轴性近视的眼睛的青光眼。横断面研究。纳入非轴性近视青光眼368眼和健康眼411眼，轻度轴性近视青光眼393眼和健康眼271眼，高度轴性近视青光眼124眼和健康眼85眼。比较整体和扇形视乳头周围视网膜神经纤维层厚度 (pRNFLT)、布鲁赫膜开口最小边缘宽度 (BMO-MRW)、神经节细胞内丛状层厚度 (GCIPLT) 和黄斑 RNFLT (mRNFLT) 以及青光眼检测的诊断准确性使用调整后的受试者工作特征曲线下面积（AUC）进行评估。 ONH 和黄斑参数检测青光眼的诊断准确性普遍较高，且因近视人群而异。对于 ONH 参数，高度近视的整体 (AUC = 0.95) 和颞下 (AUC = 0.91) pRNFLT 以及非近视 (AUC = 1.0) 和轻度近视 (AUC = 0.97) 的整体 BMO-MRW 的诊断准确性最高。对于黄斑参数，与没有 AUC > 0.90 的非高度近视相比，高度近视的诊断准确性更高，11 个 GCIPLT 全球/部门中有 6 个调整了 AUC > 0.90。在所有近视组中，mRNFLT 的 AUC 均低于 GCIPLT。 pRNFL 和 GCIPL 对于高度近视眼的诊断准确性很高，并且显示出在高度近视眼中青光眼检测方面的前景。需要进一步分析以确定是否可以在其他人群中证实高诊断准确性。