To investigate the repeatability and agreement of corneal astigmatism measurements in eyes with irregular corneal astigmatism component (ICAC) using four devices: IOLMaster 700 biometer, Lenstar 900 biometer, iTrace, and Pentacam. Prospective cross-sectional reliability analysis. Sixty-four eyes (52 patients) with ICAC were examined three times using the four devices. The eye with ICAC in this study is defined as the cornea has a certain degree of irregular astigmatism (asymmetric and/or skewed bowtie pattern of corneal topography according to corneal topography classification), accompanied with total corneal higher-order aberrations in the 4 mm zone of 0.3 µm or greater. Corneal astigmatism was evaluated using three categories: anterior corneal astigmatism (ACA), posterior corneal astigmatism, and total corneal astigmatism (TCA). The repeatability was determined using the ∆Ast (arithmetic mean of vector differences among three repeated corneal astigmatism measurements). Bland–Altman plots and astigmatism vector analyses were employed to assess agreement. The IOLMaster 700 (∆Ast = 0.27 ± 0.20 D) showcased higher repeatability in ACA measurements compared to iTrace (∆Ast = 0.37 ± 0.38 D, = .040) and Pentacam (∆Ast = 0.50 ± 0.22 D, < .001), and paralleled the performance of Lenstar 900 (∆Ast = 0.31 ± 0.26 D, = .338). The Pentacam (∆Ast = 0.09 ± 0.07 D, < .001) demonstrated superior repeatability in posterior corneal astigmatism, whereas the IOLMaster 700 (∆Ast = 0.33 ± 0.23 D, < .001) excelled in TCA. The IOLMaster 700 exhibited good agreement with either Lenstar 900 or iTrace, characterized by narrow 95% limits of agreement and clinically acceptable vector differences. Conversely, vector differences between Pentacam and the other three devices in ACA and TCA measurements were clinically significant, exceeding 0.50 D (all < .05). In terms of repeatability of corneal astigmatism measurements in eyes with ICAC, the IOLMaster 700 and Lenstar 900 outperformed iTrace and Pentacam. While the IOLMaster 700 can be used interchangeably with either Lenstar 900 or iTrace, the Pentacam is not interchangeable with the other three devices.

中文翻译：

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4种生物计测量角膜散光不规则眼的重复性和一致性


为了研究使用四种设备对具有不规则角膜散光成分 (ICAC) 的眼睛进行角膜散光测量的可重复性和一致性：IOLMaster 700 生物计、Lenstar 900 生物计、iTrace 和 Pentacam。前瞻性横截面可靠性分析。使用四种设备对 64 只患有 ICAC 的眼睛（52 名患者）进行了 3 次检查。本研究中的ICAC眼被定义为角膜有一定程度的不规则散光（根据角膜地形图分类，角膜地形图呈不对称和/或倾斜的蝶形图案），并伴有4mm区域内的总角膜高阶像差0.3微米或更大。角膜散光使用三类进行评估：前角膜散光（ACA）、后角膜散光和总角膜散光（TCA）。使用 ΔAst（三次重复角膜散光测量之间的矢量差的算术平均值）确定重复性。采用 Bland-Altman 图和散光矢量分析来评估一致性。与 iTrace (ΔAst = 0.37 ± 0.38 D, = .040) 和 Pentacam (ΔAst = 0.50 ± 0.22 D, < .001) 相比，IOLMaster 700 (ΔAst = 0.27 ± 0.20 D) 在 ACA 测量中表现出更高的重复性，与Lenstar 900 的性能相当（ΔAst = 0.31 ± 0.26 D, = .338）。 Pentacam (ΔAst = 0.09 ± 0.07 D, < .001) 在后角膜散光方面表现出卓越的可重复性，而 IOLMaster 700 (ΔAst = 0.33 ± 0.23 D, < .001) 在 TCA 方面表现出色。 IOLMaster 700 与 Lenstar 900 或 iTrace 表现出良好的一致性，其特点是窄 95% 的一致性限制和临床可接受的矢量差异。 相反，Pentacam 与其他三种设备在 ACA 和 TCA 测量中的矢量差异具有临床显着性，超过 0.50 D（均 < .05）。在使用 ICAC 测量眼睛角膜散光的重复性方面，IOLMaster 700 和 Lenstar 900 优于 iTrace 和 Pentacam。虽然 IOLMaster 700 可以与 Lenstar 900 或 iTrace 互换使用，但 Pentacam 不能与其他三种设备互换。