This research presents an innovative reflective fiber optic probe structure, mutinously designed to detect H7N9 avian influenza virus gene precisely. This innovative structure skillfully combines multimode fiber (MMF) with a thin-diameter seven-core photonic crystal fiber (SCF-PCF), forming a semi-open Fabry-Pérot (FPI) cavity. This structure has demonstrated exceptional sensitivity in light intensity-refractive index (RI) response through rigorous theoretical and experimental validation. The development of a quasi-distributed parallel sensor array, which provides temperature compensation during measurements, has achieved a remarkable RI response sensitivity of up to 532.7 dB/RIU. The probe-type fiber optic sensitive unit, expertly functionalized with streptavidin, offers high specificity in detecting H7N9 avian influenza virus gene, with an impressively low detection limit of 10 pM. The development of this biosensor marks a significant development in biological detection, offering a practical engineering solution for achieving high sensitivity and specificity in light-intensity-modulated biosensing. Its potential for wide-ranging applications in various fields is now well-established.

中文翻译：

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用于病毒基因生物传感中高灵敏度检测的温度补偿光纤探针


这项研究提出了一种创新的反射光纤探针结构，经过精心设计，可以精确检测H7N9禽流感病毒基因。这种创新结构巧妙地将多模光纤（MMF）与细直径七芯光子晶体光纤（SCF-PCF）结合在一起，形成半开放法布里-珀罗（FPI）腔。通过严格的理论和实验验证，该结构在光强度-折射率 (RI) 响应方面表现出卓越的灵敏度。准分布式并行传感器阵列的开发可在测量过程中提供温度补偿，已实现高达 532.7 dB/RIU 的卓越 RI 响应灵敏度。探针型光纤敏感单元采用链霉亲和素进行专业功能化，在检测 H7N9 禽流感病毒基因方面具有高特异性，检测限低至 10 pM，令人印象深刻。这种生物传感器的开发标志着生物检测的重大发展，为实现光强调制生物传感的高灵敏度和特异性提供了实用的工程解决方案。它在各个领域广泛应用的潜力现已得到证实。