The therapeutic potential of fucoidan (FUC), a natural polysaccharide, in metabolic disorders is recognized, yet its underlying mechanisms remain unclear. We conducted investigations into the therapeutic mechanisms of FUC sourced from concerning metabolic disorders induced by a high-sucrose diet (HSD), employing and mice models. larvae were subjected to HSD exposure to monitor growth inhibition, reduced pupation, and developmental delays. Additionally, we examined the impact of FUC on growth- and development-related hormones in . Furthermore, we assessed the modulation of larval intestinal homeostasis by FUC, focusing on the regulation of Notch signaling. In mice, we evaluated the effects of FUC on HSD-induced impairments in intestinal epithelial barrier integrity and gut hormone secretion. FUC supplementation significantly enhanced pupal weight in larvae and effectively countered HSD-induced elevation of glucose and triglyceride levels. It notably influenced the expression of growth- and development-related hormones, particularly augmenting insulin-like peptides production while mitigating larval growth retardation. FUC also modulated larval intestinal homeostasis by negatively regulating Notch signaling, thereby protecting against HSD-induced metabolic stress. In mice, FUC ameliorated HSD-induced impairments in ileum epithelial barrier integrity and gut hormone secretion. Our findings demonstrate the multifaceted therapeutic effects of FUC in mitigating metabolic disorders and maintaining intestinal health. FUC holds promise as a therapeutic agent, with its effects attributed partly to the sulfate group and its ability to regulate Notch signaling, emphasizing its potential for addressing metabolic disorders.

中文翻译：

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褐藻糖胶通过调节 Notch 信号传导缓解高蔗糖诱导的代谢紊乱并增强肠道稳态


岩藻依聚糖（FUC）是一种天然多糖，其在代谢紊乱中的治疗潜力已得到认可，但其潜在机制仍不清楚。我们利用小鼠模型，对高蔗糖饮食（HSD）引起的代谢紊乱相关的 FUC 的治疗机制进行了研究。幼虫暴露于HSD以监测生长抑制、化蛹减少和发育延迟。此外，我们还研究了 FUC 对生长和发育相关激素的影响。此外，我们评估了 FUC 对幼虫肠道稳态的调节，重点关注 Notch 信号传导的调节。在小鼠中，我们评估了 FUC 对 HSD 引起的肠上皮屏障完整性和肠道激素分泌损伤的影响。补充 FUC 显着增加幼虫的蛹重量，并有效对抗 HSD 引起的葡萄糖和甘油三酯水平升高。它显着影响生长和发育相关激素的表达，特别是增加胰岛素样肽的产生，同时减轻幼虫生长迟缓。 FUC 还通过负向调节 Notch 信号传导来调节幼虫肠道稳态，从而防止 HSD 诱导的代谢应激。在小鼠中，FUC 改善了 HSD 引起的回肠上皮屏障完整性和肠道激素分泌损伤。我们的研究结果证明了 FUC 在减轻代谢紊乱和维持肠道健康方面的多方面治疗作用。 FUC 有望成为一种治疗剂，其作用部分归因于硫酸基团及其调节 Notch 信号传导的能力，强调了其解决代谢紊乱的潜力。