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Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans
Environmental Toxicology and Pharmacology ( IF 4.2 ) Pub Date : 2024-05-31 , DOI: 10.1016/j.etap.2024.104480 Neha Sharma 1 , Vinay Kumar 2 , Vimal S 1 , Mridul Umesh 3 , Preeti Sharma 4 , Basheer Thazeem 5 , Komalpreet Kaur 6 , Jithin Thomas 7 , Ritu Pasrija 4 , Divya Utreja 8
Environmental Toxicology and Pharmacology ( IF 4.2 ) Pub Date : 2024-05-31 , DOI: 10.1016/j.etap.2024.104480 Neha Sharma 1 , Vinay Kumar 2 , Vimal S 1 , Mridul Umesh 3 , Preeti Sharma 4 , Basheer Thazeem 5 , Komalpreet Kaur 6 , Jithin Thomas 7 , Ritu Pasrija 4 , Divya Utreja 8
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Endocrine disrupting chemicals or carcinogens have been known for decades for their endocrine signal disruption. Endocrine disrupting chemicals are a serious concern and they have been included in the top priority toxicants and persistent organic pollutants. Therefore, researchers have been working for a long time to understand their mechanisms of interaction in different human organs. Several reports are available about the carcinogen potential of these chemicals. The presented review is an endeavor to understand the hazard identification associated with endocrine disrupting carcinogens in relation to the human body. The paper discusses the major endocrine disrupting carcinogens and their potency for carcinogenesis. It discusses human exposure, route of entry, carcinogenicity and mechanisms. In addition, the paper discusses the research gaps and bottlenecks associated with the research. Moreover, it discusses the limitations associated with the analytical techniques for detection of endocrine disrupting carcinogens.
中文翻译：
与人类癌症相关的内分泌干扰致癌物 (EDC) 的危害识别
几十年来，内分泌干扰化学物质或致癌物质因其内分泌信号破坏而闻名。内分泌干扰化学品是一个严重问题，它们已被列为首要毒物和持久性有机污染物。因此，研究人员长期以来一直致力于了解它们在不同人体器官中的相互作用机制。有几份关于这些化学物质潜在致癌性的报告。本综述旨在了解与人体相关的内分泌干扰致癌物相关的危害识别。本文讨论了主要的内分泌干扰致癌物及其致癌作用。它讨论了人类接触、进入途径、致癌性和机制。此外，本文还讨论了与研究相关的研究差距和瓶颈。此外，它还讨论了与检测内分泌干扰致癌物的分析技术相关的局限性。
更新日期：2024-05-31
中文翻译：
与人类癌症相关的内分泌干扰致癌物 (EDC) 的危害识别
几十年来，内分泌干扰化学物质或致癌物质因其内分泌信号破坏而闻名。内分泌干扰化学品是一个严重问题，它们已被列为首要毒物和持久性有机污染物。因此，研究人员长期以来一直致力于了解它们在不同人体器官中的相互作用机制。有几份关于这些化学物质潜在致癌性的报告。本综述旨在了解与人体相关的内分泌干扰致癌物相关的危害识别。本文讨论了主要的内分泌干扰致癌物及其致癌作用。它讨论了人类接触、进入途径、致癌性和机制。此外，本文还讨论了与研究相关的研究差距和瓶颈。此外，它还讨论了与检测内分泌干扰致癌物的分析技术相关的局限性。
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