Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors,Environmental Toxicology and Pharmacology

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Indole-3-acetic acid induced cardiogenesis impairment in in-vivo zebrafish via oxidative stress and downregulation of cardiac morphogenic factors
Environmental Toxicology and Pharmacology ( IF 4.2 ) Pub Date : 2024-05-29 , DOI: 10.1016/j.etap.2024.104479
S P Ramya Ranjan Nayak ₁ , Seenivasan Boopathi ₁ , Bader O Almutairi ₂ , Selvaraj Arokiyaraj ₃ , M K Kathiravan ₄ , Jesu Arockiaraj ₁

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Plant growth regulators (PGRs) are increasingly used to promote sustainable agriculture, but their unregulated use raises concerns about potential environmental risks. Indole-3-acetic acid (IAA), a commonly used PGR, has been the subject of research on its developmental toxicity in the in-vivo zebrafish model. IAA exposure to zebrafish embryos caused oxidative stress, lipid peroxidation, and cellular apoptosis. The study also revealed that critical antioxidant genes including , , and were downregulated, while pro-apoptotic genes such as and were upregulated. IAA exposure also hampered normal cardiogenesis by downregulating , , and genes and potentially influencing zebrafish neurobehavior. The accumulation of IAA was confirmed by HPLC analysis of IAA-exposed zebrafish tissues. These findings underscore the need for further study on the potential ecological consequences of IAA use and the need for sustainable agricultural practices.

中文翻译：

3-吲哚乙酸通过氧化应激和心脏形态发生因子下调诱导体内斑马鱼心脏发生损伤

植物生长调节剂（PGR）越来越多地用于促进可持续农业，但其不受监管的使用引起了人们对潜在环境风险的担忧。吲哚-3-乙酸（IAA）是一种常用的植物生长调节剂（PGR），一直是其在斑马鱼体内模型中发育毒性研究的主题。斑马鱼胚胎暴露于 IAA 会导致氧化应激、脂质过氧化和细胞凋亡。研究还表明，关键的抗氧化基因，包括、、和被下调，而促凋亡基因，如和被上调。 IAA 暴露还通过下调、和基因并可能影响斑马鱼的神经行为来阻碍正常的心脏发生。通过对暴露于 IAA 的斑马鱼组织进行 HPLC 分析，证实了 IAA 的积累。这些发现强调需要进一步研究 IAA 使用的潜在生态后果以及可持续农业实践的必要性。

更新日期：2024-05-29

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