Research progress on GPX4 targeted compounds,European Journal of Medicinal Chemistry

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Research progress on GPX4 targeted compounds
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2024-05-31 , DOI: 10.1016/j.ejmech.2024.116548
Bingru Li ₁ , Keguang Cheng ₂ , Tzumei Wang ₁ , Xing Peng ₃ , Ping Xu ₁ , Guoquan Liu ₁ , Dong Xue ₄ , Ning Jiao ₅ , Chao Wang ₁

Affiliation

Blocking the System X GSHGPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein, including inhibitors, activators, small molecule degraders, chimeric degraders, and the application of combination therapies with other drugs, aiming to promote further research on the target and related diseases.

中文翻译：

GPX4靶向化合物的研究进展

阻断 System X GSHGPX4 途径以诱导肿瘤细胞铁死亡是一种新的癌症治疗策略。 GPX4 是 System Xc-/GSH/GPX4 途径的核心，是诱导肿瘤细胞铁死亡的主要靶标。本文总结了目前研究中发现的直接靶向GPX4蛋白的化合物，包括抑制剂、激活剂、小分子降解剂、嵌合降解剂，以及与其他药物联合治疗的应用，旨在推动对该靶点及相关疾病的进一步研究。

更新日期：2024-05-31

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