Nanostructured multiphase (NM) alloys have attracted extensive attention due to their superior mechanical properties. However, it is still a great challenge to effectively design and produce large-scale NM alloys. Here, utilizing the intermediate-temperature instability of high entropy alloys (HEAs), we propose a new approach to rapidly design and effectively produce bulk NM alloys. The key to our design approach includes the “destabilization strategy” to destabilize the single-phase HEA, and the “self-optimization” strategy to rapidly identify the composition of NM alloys. We developed a bulk NM alloy with a hardness of up to ∼1378 HV. Such a high hardness originates from a two-stage phase decomposition behaviour at intermediate temperatures and the formation of a unique coherent multiphasic nanostructure. This design strategy not only effectively guides the discovery of novel NM alloys from the immense compositional space of HEAs, but also enables the large-scale synthesis of NM alloys.

纳米结构多相（NM）合金因其优异的机械性能而受到广泛关注。然而，有效设计和生产大规模纳米金属合金仍然是一个巨大的挑战。在这里，我们利用高熵合金 (HEA) 的中温不稳定性，提出了一种快速设计和有效生产块体 NM 合金的新方法。我们设计方法的关键包括使单相 HEA 不稳定的“失稳策略”，以及快速识别 NM 合金成分的“自优化”策略。我们开发了一种硬度高达 ∼1378 HV 的块状 NM 合金。如此高的硬度源于中间温度下的两阶段相分解行为以及独特的连贯多相纳米结构的形成。这种设计策略不仅有效指导从HEA巨大的成分空间中发现新型NM合金，而且使NM合金的大规模合成成为可能。