Degradable Microneedle Patch with Photothermal-Promoted Bacteria-Infected Wound Healing and Microenvironment Remodeling,ACS Applied Materials & Interfaces

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Degradable Microneedle Patch with Photothermal-Promoted Bacteria-Infected Wound Healing and Microenvironment Remodeling
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2024-06-14 , DOI: 10.1021/acsami.4c04414
Xinjie Yin ₁ , Jie Wei ₁ , Jinhong Hou ₁ , Suying Xu ₁ , Leyu Wang ₁

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Bacteria-infected wound healing is one of the most challenging issues in health management that is attracting worldwide concerns. Despite great achievements with antibiotics, emergence of antibiotic-resistance retarded the wound healing process and also led to severe outcomes. Exploration of novel antibiotics together with amelioration of wound healing efficacy is desirable. Herein, a degradable microneedle patch (AAZH@MNs) was fabricated through incorporating near-infrared light responsive photothermal agents for sustained bacteria killing and prevention of biofilm formation. In addition, the antibacterial microneedle patch could even remold the microenvironment of bacteria-infected wounds through an antibacterial effect, significantly facilitating the wound healing process.

中文翻译：

可降解微针贴片具有光热促进细菌感染伤口愈合和微环境重塑的作用

细菌感染的伤口愈合是健康管理中最具挑战性的问题之一，引起了全世界的关注。尽管抗生素取得了巨大成就，但抗生素耐药性的出现阻碍了伤口愈合过程，并导致了严重的后果。探索新型抗生素以及改善伤口愈合功效是值得期待的。在此，通过掺入近红外光响应光热剂来制造可降解微针贴片（AAZH@MNs），以持续杀灭细菌并防止生物膜形成。此外，抗菌微针贴片甚至可以通过抗菌作用重塑细菌感染伤口的微环境，显着促进伤口愈合过程。

更新日期：2024-06-14

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