An efficient strategy has been developed for the synthesis of 3-substituted lawsones using a catalytic amount of Sc(OTf)3 in toluene at -78 °C through a Buchner-Curtius-Schlotterbeck reaction. It is a versatile method to produce a large number of 3-aryl, 3-styryl, 3-alkyl, and 3-heteroaryl substituted lawsones under mild conditions. This is a first report on the synthesis of 3-substituted lawsones in high to excellent yields in short reaction times.

中文翻译：

---

Sc(OTf)3 催化 Buchner-Curtius-Schlotterbeck 反应合成 3-取代的 Lawsones


我们开发了一种有效的策略，通过布赫纳-库尔蒂斯-施洛特贝克反应，在-78 °C 的甲苯中使用催化量的 Sc(OTf)3 合成 3-取代的指甲花酮。它是一种在温和条件下生产大量3-芳基、3-苯乙烯基、3-烷基和3-杂芳基取代的指甲花酮的通用方法。这是关于在短反应时间内以高至优异的产率合成 3-取代的指甲花酮的第一份报告。