Light-driven cancer theranostics has shown inexhaustible and vigorous vitality by virtue of its high efficacy, prominent controllability and noninvasiveness. Exploration of an all-round theranostic material simultaneously affording both multimodal diagnosis imaging and synergistic phototherapy would be an appealing yet significantly challenging task. Herein, a novel nanomedicine Ir@PPEG-MeEPO was ingeniously constructed by integrating beforehand ¹O₂-charged amphiphilic polymer and well-tailored Ir(III) complex IrDPTP, which was featured by second near-infrared (NIR-II) aggregation-induced emission (AIE) tendency, efficient reactive oxygen species (ROS) generation, good photothermal conversion efficiency and high-performance hydrogen gas production. To the best of our knowledge, IrDPTP held the longest emission wavelength among all reported AIE Ir (III) complexes. Moreover, Ir@PPEG-MeEPO was capable of controllably releasing ROS via triggered photothermal effect upon NIR irradiation, making it well-adapted to hypoxic environment of tumor. Those distinctive characteristics of Ir@PPEG-MeEPO endowed it with unprecedented performance on sextuple theranostics comprised of NIR-II fluorescence-photoacoustic-photothermal trimodal imaging and photodynamic-photothermal-hydrogen trimodal therapy, witnessed by the precise tumor diagnosis and complete tumor elimination. The study would open up new perspectives for the exploration of superior nanomedicine for practical cancer theranostics.

光驱动的肿瘤治疗以其高效、可控性和非侵入性等特点，展现出不竭而旺盛的生命力。探索同时提供多模式诊断成像和协同光疗的全方位治疗诊断材料将是一项有吸引力但极具挑战性的任务。在此，通过集成预先 ¹ O ₂ 带电荷的两亲性聚合物和精心设计的Ir(III)配合物IrDPTP，巧妙地构建了一种新型纳米药物Ir@PPEG-MeEPO，其特点是第二近红外（NIR-II）聚集诱导发射（AIE）趋势，高效的活性氧（ROS）产生，良好的光热转换效率和高性能的氢气生产。据我们所知，IrDPTP 在所有报道的 AIE Ir (III) 配合物中具有最长的发射波长。此外，Ir@PPEG-MeEPO能够通过近红外照射触发的光热效应可控地释放ROS，使其能够很好地适应肿瘤的缺氧环境。 Ir@PPEG-MeEPO的这些独特特性使其在由NIR-II荧光-光声-光热三模态成像和光动力-光热-氢三模态治疗组成的六重治疗诊断方面具有前所未有的性能，并以精确的肿瘤诊断和彻底的肿瘤消除为证。该研究将为探索实用癌症治疗学的优质纳米医学开辟新的视角。