This study aimed to compare tumor lesion detectability and diagnostic accuracy of whole-body magnetic resonance imaging (WB-MRI) and radioiodine-labeled meta-iodo-benzylguanidine (mIBG) imaging techniques in patients with metastatic pheochromocytoma and paraganglioma (PPGL). This retrospective study included 13 patients had pheochromocytoma and 5 had paraganglioma, who were all suspected of having metastatic tumors. Each patient underwent WB-MRI and ¹²³I-mIBG as a pretreatment screening for ¹³¹I-mIBG therapy. Two expert reviewers evaluated WB-MRI, ¹²³I-mIBG images, and post-therapy ¹³¹I-mIBG images for the presence of metastatic lesions in the lungs, bones, liver, lymph nodes, and other organs. Diagnostic measures for detecting metastatic lesions, including sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristics (ROC)—area under the curve (AUC), were calculated for each imaging technique. We analyzed WB-MRI images for detecting metastatic lesions, which demonstrated sensitivity, specificity, accuracy, PPV, NPV, and AUC of 82%, 97%, 90%, 96%, 86%, and 0.92, respectively. These values were 83%, 95%, 89%, 94%, 86%, and 0.90 in ¹²³I-mIBG images and 85%, 92%, 89%, 91%, 87%, and 0.91 in post-therapy ¹³¹I-mIBG images, respectively. Our results reveal the comparable diagnostic accuracy of WB-MRI to one of the mIBG images.

本研究旨在比较全身磁共振成像（WB-MRI）和放射性碘标记间碘苄基胍（ m IBG）成像技术对转移性嗜铬细胞瘤和副神经节瘤（PPGL）患者肿瘤病灶的可检出性和诊断准确性。这项回顾性研究包括 13 名嗜铬细胞瘤患者和 5 名副神经节瘤患者，均怀疑患有转移性肿瘤。每个患者均接受 WB-MRI 和¹²³ I- m IBG 作为¹³¹ I- m IBG 治疗的预处理筛查。两名专家评审员评估了 WB-MRI、 ¹²³ I- m IBG 图像和治疗后¹³¹ I- m IBG 图像，以确定肺、骨骼、肝脏、淋巴结和其他器官中是否存在转移灶。针对每种成像技术计算了检测转移性病变的诊断措施，包括敏感性、特异性、准确性、阳性​​预测值 (PPV)、阴性预测值 (NPV) 和受试者操作特征 (ROC)——曲线下面积 (AUC) 。我们分析了用于检测转移性病灶的 WB-MRI 图像，其敏感性、特异性、准确性、PPV、NPV 和 AUC 分别为 82%、97%、90%、96%、86% 和 0.92。在^{123 个}I- m IBG 图像中，这些值分别为 83%、95%、89%、94%、86% 和 0.90，在治疗后^{131 个}图像中，这些值为 85%、92%、89%、91%、87% 和 0.91。分别为 I- m IBG 图像。我们的结果揭示了 WB-MRI 与m 个IBG 图像之一的诊断准确性相当。