Hospitalized patients with urinary tract infection (UTI) often receive treatment with extended-spectrum antibiotics while waiting for culture results, as a precaution in case of multidrug-resistant organism (MDRO) infections. However, most of these patients could be treated with standard-spectrum antibiotics.

In the cluster-randomized INSPIRE trial, the effect of the new INSPIRE antibiotic stewardship bundle on empiric extended-spectrum antibiotic prescriptions for hospitalized patients with UTI was assessed, and the results were published in JAMA. The INSPIRE stewardship bundle consists of computerized provider order entry (CPOE) prompts recommending standard-spectrum antibiotics for patients with low estimated absolute risk of MDRO infection (<10%), combined with education and feedback.

住院的尿路感染 (UTI) 患者通常在等待培养结果时接受广谱抗生素治疗，以预防多重耐药菌 (MDRO) 感染。然而，大多数患者可以使用标准谱抗生素进行治疗。

在整群随机 INSPIRE 试验中，评估了新的 INSPIRE 抗生素管理捆绑包对 UTI 住院患者经验性广谱抗生素处方的影响，结果发表在JAMA上。 INSPIRE 管理包包括计算机化的供应商订单输入 (CPOE) 提示，为估计 MDRO 感染绝对风险较低（<10%）的患者推荐标准谱抗生素，并结合教育和反馈。