A recent study published in Cell Metabolism has investigated the effect of intermittent fasting on nonalcoholic steatohepatitis (NASH) and NASH-related hepatocellular carcinoma (HCC) in mice.

First, the researchers demonstrated that Western diet-fed mice put on an intermittent fasting regimen (consisting of 2 non-consecutive days of fasting per week) were resistant to obesity and had significantly less NASH and fibrosis development compared with non-fasting control mice, and the benefits were independent of total calorie consumption. Further in vivo experiments in mouse models of NASH established that the benefits varied according to what time of day fasting was initiated, as well as the amount and duration of fasting cycles.

最近发表在《细胞代谢》杂志上的一项研究调查了间歇性禁食对小鼠非酒精性脂肪性肝炎 (NASH) 和 NASH 相关肝细胞癌 (HCC) 的影响。

首先，研究人员证明，与非禁食对照小鼠相比，西方饮食喂养的小鼠采用间歇性禁食方案（包括每周非连续 2 天禁食）能够抵抗肥胖，并且 NASH 和纤维化的发展显着减少。并且其益处与总热量消耗无关。在 NASH 小鼠模型中进行的进一步体内实验表明，益处根据一天中开始禁食的时间以及禁食周期的数量和持续时间而变化。