Nanodynamic therapy (NDT) as an effective candidate strategy has made great achievements in the treatment of tumors, bacterial infections and other related diseases. However, the in vivo therapeutic effect of traditional NDT is heavily dependent on the tissue microenvironment, but which is often hypoxic and absence of H2O2. Therefore, a new strategy that is insensitive to the concentration of oxygen and H2O2 in the tissue microenvironment is necessary. Electrodynamic therapy (EDT) is a new type of NDT that generates reactive oxygen species by dissociating water under alternating current introduction, which is considered as a promising solution strategy. This tutorial review is firstly intended to provide an introduction of the current advances in EDT for anticancer and anti-infection therapy, which covers topics from the electrosensitizer classified by the types of platforms, to the EDT-based therapy including mono- and bimodal synergistic therapy, as well as the researches of the treatment applications (anticancer applications and bacterial infection) are also discussed. Finally, the current status and future prospects of EDT are summarized. We hope that this timely and comprehensive review will shed light on the value and future prospects of EDT, and that further research is needed to achieve its further development.

中文翻译：

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电动疗法：用于抗癌和抗感染治疗的新型纳米动力学策略


纳米动力学疗法 （NDT） 作为一种有效的候选策略，在治疗肿瘤、细菌感染和其他相关疾病方面取得了巨大成就。然而，传统无损检测的体内治疗效果在很大程度上取决于组织微环境，但通常是缺氧且缺乏 H 2 O 2 的。因此，需要一种对组织微环境中的氧气和 H 2 O 2 浓度不敏感的新策略。电动疗法 （EDT） 是一种新型的无损检测，通过在交流电引入下解离水来产生活性氧，这被认为是一种很有前途的解决方案。本教程综述首先旨在介绍当前 EDT 在抗癌和抗感染治疗中的进展，其中涵盖了从按平台类型分类的电敏剂到基于 EDT 的疗法（包括单峰和双峰协同疗法）的主题，以及治疗应用（抗癌应用和细菌感染）的研究。最后，对 EDT 的现状和未来展望进行了总结。我们希望这次及时而全面的审查能够阐明 EDT 的价值和未来前景，并且需要进一步的研究以实现其进一步发展。