We have previously reported that the interleukin-23 p19 subunit (IL-23p19) is required for experimental inflammatory arthritic pain-like behavior and disease. Even though inflammation is often a characteristic feature of osteoarthritis (OA), IL-23 is not usually considered as a therapeutic target in OA. We began to explore the role of IL-23p19 in OA pain and disease utilizing mouse models of OA and patient samples.

中文翻译：

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IL-23p19 在骨关节炎性疼痛和疾病中的应用


我们之前已经报道过白细胞介素 23 p19 亚基 （IL-23p19） 是实验性炎症性关节炎疼痛样行为和疾病所必需的。尽管炎症通常是骨关节炎 （OA） 的一个特征，但 IL-23 通常不被视为 OA 的治疗靶点。我们开始利用 OA 小鼠模型和患者样本探索 IL-23p19 在 OA 疼痛和疾病中的作用。