Differentiation of human primordial germ cells (hPGCs) to mitotic spermatogonia and oogonia occurring through epigenetic reprogramming is a fundamental process of development. hPGC-like cells (hPGCLCs) have been successfully induced in vitro starting from human pluripotent stem cells (hPSCs) but have low efficiency and are prone to de-differentiation.

In a paper published in Nature, the authors established a signalling-molecule-dependent system to differentiate hPGCLCs in vitro.

中文翻译：

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一种新的基于信号传导的生殖细胞重编程系统

通过表观遗传重编程发生的人类原始生殖细胞（hPGC）分化为有丝分裂精原细胞和卵原细胞是发育的基本过程。人类多能干细胞（hPSC）已成功在体外诱导hPGC样细胞（hPGCLC），但效率低且易于去分化。

在《自然》杂志上发表的一篇论文中，作者建立了一种信号分子依赖性系统来体外分化 hPGCLC。