Membrane-based microfluidic systems for medical and biological applications,Lab on a Chip

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Membrane-based microfluidic systems for medical and biological applications
Lab on a Chip ( IF 6.1 ) Pub Date : 2024-06-13 , DOI: 10.1039/d4lc00251b
Silvia Tea Calzuola _{1,

2} , Gwenyth Newman _{2,

3} , Thomas Feaugas _{2,

3} , Cécile M Perrault ₂ , Jean-Baptiste Blondé ₂ , Emmanuel Roy ₂ , Constance Porrini ₂ , Goran M Stojanovic ₄ , Jasmina Vidic ₅

Affiliation

Microfluidic devices with integrated membranes that enable control of mass transport in constrained environments have shown considerable growth over the last decade. Membranes are a key component in several industrial processes such as chemical, pharmaceutical, biotechnological, food, and metallurgy separation processes as well as waste management applications, allowing for modular and compact systems. Moreover, the miniaturization of a process through microfluidic devices leads to process intensification together with reagents, waste and cost reduction, and energy and space savings. The combination of membrane technology and microfluidic devices allows therefore magnification of their respective advantages, providing more valuable solutions not only for industrial processes but also for reproducing biological processes. This review focuses on membrane-based microfluidic devices for biomedical science with an emphasis on microfluidic artificial organs and organs-on-chip. We provide the basic concepts of membrane technology and the laws governing mass transport. The role of the membrane in biomedical microfluidic devices, along with the required properties, available materials, and current challenges are summarized. We believe that the present review may be a starting point and a resource for researchers who aim to replicate a biological phenomenon on-chip by applying membrane technology, for moving forward the biomedical applications.

中文翻译：

用于医疗和生物应用的基于膜的微流体系统

具有集成膜的微流体装置能够在受限环境中控制质量传输，在过去十年中显示出可观的增长。膜是化学、制药、生物技术、食品和冶金分离过程以及废物管理应用等多种工业过程中的关键组件，可实现模块化和紧凑型系统。此外，通过微流体装置实现工艺的小型化可实现工艺强化以及试剂、废物和成本的减少以及能源和空间的节省。因此，膜技术和微流体装置的结合可以放大它们各自的优势，不仅为工业过程而且为再现生物过程提供更有价值的解决方案。本综述重点关注生物医学领域的基于膜的微流体装置，重点是微流体人造器官和芯片上的器官。我们提供膜技术的基本概念和质量传输的规律。总结了膜在生物医学微流体装置中的作用，以及所需的特性、可用材料和当前的挑战。我们相信，本综述可能是研究人员的一个起点和资源，他们的目标是通过应用膜技术在芯片上复制生物现象，以推进生物医学应用。

更新日期：2024-06-13

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