Catalyst-free reaction of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates: synthesis of 1,2-dihydroquinolines and 2,3-dihydropyrroles,Chemical Communications

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Catalyst-free reaction of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates: synthesis of 1,2-dihydroquinolines and 2,3-dihydropyrroles
Chemical Communications ( IF 4.3 ) Pub Date : 2024-06-13 , DOI: 10.1039/d4cc02156h
Tao Wang ₁ , Zhongyue Lu ₁ , Pengfei Li ₁

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Catalyst-free annulations of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates have been successfully achieved under mild conditions. Specifically, the reaction of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates with sulfur ylides furnished various 1,2-dihydroquinolines in generally high yields. Furthermore, [3+2]-annulations of 2-(4H-benzo[d][1,3]oxazin-4-yl)acrylates with α,β-unsaturated imines afforded a broad scope of polysubstituted 2,3-dihydropyrroles with high efficiency.

中文翻译：

2-(4H-苯并[d][1,3]恶嗪-4-基)丙烯酸酯的无催化剂反应：合成1,2-二氢喹啉和2,3-二氢吡咯

在温和条件下成功实现了 2-(4 H-苯并[ d ][1,3]恶嗪-4-基)丙烯酸酯的无催化剂成环。具体而言，2-(4 H-苯并[ d ][1,3]恶嗪-4-基)丙烯酸酯与硫叶立德的反应通常以高收率提供各种1,2-二氢喹啉。此外，2-(4 H-苯并[ d ][1,3]恶嗪-4-基)丙烯酸酯与α,β-不饱和亚胺的[3+2]-环化提供了广泛的多取代2,3-二氢吡咯效率高。

更新日期：2024-06-18

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