Relay Annulation of Ammonium Ylides with Oxindole-Derived α,β-Unsaturated Ketimines: Catalytic Construction of Spiro-polycyclic Oxindoles,Organic Letters

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Relay Annulation of Ammonium Ylides with Oxindole-Derived α,β-Unsaturated Ketimines: Catalytic Construction of Spiro-polycyclic Oxindoles
Organic Letters ( IF 4.9 ) Pub Date : 2024-06-11 , DOI: 10.1021/acs.orglett.4c01442
Wei-Hao Zheng ₁ , Jing-Fang Lv ₁ , Shi-Mei He ₁ , Ning Yu ₁ , Yu-Qiang Zhou ₁ , Yun-Bo Yang ₁ , Lv-Yan Liu ₁ , Kui-Cheng He ₁ , Ye Wei ₁ , Kun Jiang ₁

Affiliation

An ammonium ylide-based relay annulation was disclosed, which uses DABCO as the catalyst and oxindole-derived α,β-unsaturated ketimines and γ-bromo-crotonates as the starting materials. This method enables the rapid assembly of a series of structurally novel spiro-polycyclic oxindoles containing a bicyclo[4.1.0]heptane moiety through simultaneous generation of three new bonds and two rings in one step under mild reaction conditions.

中文翻译：

铵叶立德与羟吲哚衍生的 α,β-不饱和酮亚胺的中继成环：螺多环羟吲哚的催化构建

公开了一种基于叶立德铵的中继成环反应，其使用DABCO作为催化剂，以羟吲哚衍生的α,β-不饱和酮亚胺和γ-溴代巴豆酸酯为起始原料。该方法通过在温和的反应条件下一步同时生成三个新键和两个环，能够快速组装一系列含有双环[4.1.0]庚烷部分的结构新颖的螺多环吲哚。

更新日期：2024-06-11

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