Beyond the code: the role of histone methylation in cancer resistance and therapy,Signal Transduction and Targeted Therapy

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Beyond the code: the role of histone methylation in cancer resistance and therapy
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2024-06-12 , DOI: 10.1038/s41392-024-01878-1
Daniel Noerenberg ₁ , Frederik Damm _{1,

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Affiliation

In a recently published paper in Nature, Yamagishi et al. deliver a comprehensive exploration on the mechanistic basis and subsequent emergence of resistance of targeting histone H3 lysine trimethylation (H3K27me3) using the EZH1–EZH2 dual inhibitor, valemetostat, in adult T cell leukemia/lymphoma (ATL) patients.¹

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