An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.

中文翻译：

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PRDX6 有效利用硒可抑制铁毒性和铁死亡


铁诱导的铁死亡筛选显示 PRDX6 是一种硒蛋白合成因子。 PRDX6 的缺失显着降低了硒蛋白 GPX4（铁死亡的主要调节因子）的表达，并诱导了铁死亡。从机制上讲，PRDX6 通过充当硒输送蛋白来提高硒的利用效率。